Leo Saguiguit has appeared as soloist and chamber musician in performances at festivals and universities throughout the United States and abroad. He has also collaborated with numerous chamber ensembles throughout his career. He is a member of the Chicago Saxophone Quartet, one of the nation's oldest professional ensembles of its kind. As a member of the Lithium, Impuls, and Enigma Saxophone Quartets, he has performed throughout the country and has presented numerous premieres of works by today's rising composers. The Enigma Quartet was a prizewinner in the prestigious Fischoff National Chamber Music Competition. Saguiguit has toured America and Sweden with a chamber ensemble comprised of viola, piano, saxophone and mezzo-soprano voice. Other chamber music collaborations include performances with the Basel Saxophone Quartet of Switzerland, Thamyris Contemporary Music Ensemble, the National Black Arts Festival, and the Sewanee Music Festival.

As an orchestral saxophonist, Saguiguit has performed regularly with the Lyric Opera of Chicago, Milwaukee Symphony, Grant Park Music Festival Orchestra, Atlanta Symphony, and the Florida Orchestra. He has also performed with the professional wind ensembles Philharmonia à Vent and the New Sousa Band. Saguiguit has appeared as soloist with numerous orchestras and wind ensembles, including a recent tour of France. He is also featured in premiere recordings on CD of the music of Luc Marcel and John David Lamb.

Saguiguit has served as director of the Sewanee Summer Music Center & Festival. As conductor, he was music director of the Atlanta Youth Wind Symphony and led various collegiate ensembles. Prior to his recent appointment at the University of Missouri-Columbia, Saguiguit taught on the music performance faculty at Northwestern University for three years and the woodwind, theory, and conducting faculty of Emory University for seven years. He has also served on the faculties of Truett-McConnell College, the National High School Music Institute, and the Merit School of Music. He earned degrees from Emory University and Northwestern University, where he was a student of Frederick L. Hemke. Other teachers include Stutz Wimmer, Paul Bro, and Jonathan Helton.